ABSTRACT
SESSION TITLE: Biological Markers in Patients with COVID-19 Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/18/2022 01:30 pm - 02:30 pm PURPOSE: C-REACTIVE PROTEIN (CRP) is an acute phase reactant produced by liver in response to cytokines especially Interleukin-6 (IL-6). CRP consists of five identical subunits arranged symmetrically around a central pore. CRP binds to phospholipid constituents of foreign pathogens and damaged cells to promote the elimination of pathogens and clearance of apoptotic cells. Covid 19 virus through the spike protein binds to Angiotensin Converting Enzyme 2 receptors of host target cells, particularly receptors of alveolar Type 2 epithelial cells. This reaction causes Cytokine storm syndrome with release of several cytokines including IL-6. The purpose of this study is to assess the significance of CRP levels in predicting mortality of Covid 19 infection induced Adult Respiratory Distress syndrome (ARDS) patients admitted in the Intensive Care Unit (ICU). METHODS: We retrospectively reviewed the records of covid 19 induced ARDS patients admitted to ICU between July 1st 2020 and June 30th 2021 in a community hospital. We collected the CRP level on admission and discharge (survived or deceased) during that admission. The discharge CRP level was subtracted from admission CRP level. The positive value was taken as elevated CRP level and negative value was taken as non-elevated CRP. RESULTS: A total of 484 covid patients were admitted at the ICU during that period. Of those, 228 patients had admission and discharge (survived or deceased) CRP lab value available. 177 patients survived with 33 (18.6%) had elevated CRP and 144 (81.4%) had non-elevated CRP levels. 51 patients deceased with 32 (62.7%) had elevated CRP and 10 (37.3%) had non-elevated CRP levels. The p-value is <.00001. CONCLUSIONS: Elevated CRP was associated with high ICU mortality in Covid 19 infected ARDS patients. CLINICAL IMPLICATIONS: CRP can be elevated initially due to Cytokine storm syndrome and later may be related to secondary infection especially with immunosuppressive treatment. Elevated CRP levels indicates higher inflammatory response which should prompt early appropriate intervention. DISCLOSURES: No relevant relationships by Ravi Chandran No relevant relationships by Pranav Vadhul